The Effect of Chronic Cerebral Hypoperfusion on Alzheimer's Disease and the Protective Effects of Antioxidant Functional Foods.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K19666
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Okayama University (2021); 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨床研究部(循環器)) (2020)
• Principal Investigator: FUKUI Yusuke 岡山大学, 大学病院, 助教 (60824802)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: アルツハイマー病 / 慢性脳低灌流 / プラズマローゲン

Outline of Final Research Achievements

In this study, we analyzed the pathway from oxidative stress caused by chronic cerebral hypoperfusion to cognitive dysfunction, and investigated the possibility of developing new preventive and therapeutic methods for Alzheimer's disease (AD). The ameriod constrictors were placed in the common carotid artery of AD model mice (APP23), and cerebral blood flow was reduced by 40% over a period of about 1 month.　APP23 mice showed faster than normal spatial cognitive function and deterioration of blood oxidative stress levels due to reduced cerebral blood flow, but these deteriorations were ameliorated by plasmalogene administration (APP23+CCH+Plas mice).

Free Research Field

神経病態学

Academic Significance and Societal Importance of the Research Achievements

今回の研究結果は、プラズマローゲンの継続的な摂取が血中および脳内の酸化ストレスを軽減し、脳内の炎症を抑制することで脳血流低下によるアミロイドβの蓄積および認知機能低下を緩和する可能性を示した。サプリメントなどによるホヤ由来プラズマローゲンの日常的な摂取が体内の抗酸化に働き、脳保護的な役割を果たすことが期待される。