2021 Fiscal Year Final Research Report
The migration of dietary trans fatty acid isomers in the body
Project/Area Number |
20K19704
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Fukushima University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2022-03-31
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Keywords | トランス脂肪酸 / 安定同位体 / 体燃焼性 / エライジン酸 / バクセン酸 / オレイン酸 |
Outline of Final Research Achievements |
Trans fatty acids (TFA) are considered risk factors for cardiovascular disease. However, the details of metabolism of the individual isomers are not clear. In this study, we investigated the catabolic rate of TFA isomers of octadecenoic acid (C18:1) in mice. We synthesized [1-13C]-labeled trans-C18:1 isomers (trans-4 to trans-16-C18:1). After oral administration of individual isomers to mice, we analyzed the ratio of 13C and 12C in the expired CO2 using isotope-ratio mass spectrometry. As a result, the trans-11-C18:1 was catabolized faster than other trans-C18:1 isomers. Furthermore, we found that the catabolism of trans-18:1 isomers varied in these mice. Differential catabolism in mice suggests that individual TFA isomers may play different roles in human health.
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Free Research Field |
油化学
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Academic Significance and Societal Importance of the Research Achievements |
本研究結果により、トランス脂肪酸異性体の体燃焼性を明らかにすることができた。トランス脂肪酸は、ウシなどの反芻動物の肉や乳、または植物油を水素添加して製造した硬化油に含まれる脂肪酸であり、トランス脂肪酸は我々の食生活の身近に存在している。本研究によって、トランス脂肪酸異性体の体内動態を明らかにできれば、ヒトの健康に悪影響を及ぼすトランス脂肪酸を特定する糸口になると考える。
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