Comprehensive environmental impact assessment of parent and halogenated polycyclic aromatic hydrocarbons including their metabolites

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K19985
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 64010:Environmental load and risk assessment-related
• Research Institution: University of Shizuoka
• Principal Investigator: Wang Qi 静岡県立大学, 食品栄養科学部, 特任助教 (60811685)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 多環芳香族炭化水素類（PAHs） / ハロゲン化多環芳香族炭化水素類（XPAHs） / 環境挙動 / 有害性評価 / 代謝物 / PAHsの水酸化誘導体

Outline of Final Research Achievements

In this study, a sensitive analytical method was developed for the analysis of a total of 72 polycyclic aromatic hydrocarbons (PAHs) and halogenated PAHs. The concentrations of particulate PAHs and halogenated PAHs in the atmosphere of Japan and Bangladesh were investigated and their emission sources were identified. Then, based on these results, we assessed the risk of human carcinogenicity from exposure to these pollutants. In addition, metabolites of 1-chloropyrene, a major chlorinated PAHs in the environment, were synthesized. The toxicity of several PAHs, chlorinated PAHs, and their metabolites was evaluated by in vitro tests.

Free Research Field

環境影響評価

Academic Significance and Societal Importance of the Research Achievements

既往研究と比べてより多くの種類のPAHs・ハロゲン化PAHsを網羅的に分析し、大気中における低濃度域まで汚染実態を解明したことから、これらの汚染物質に対してより高精度のリスク評価ができ、リスクベース管理の促進への貢献が期待される。また、新規合成した標準物質を用いて、in vitro試験を実施したことにより、PAHsとハロゲン化PAHsの水酸化物の毒性情報を更新し、PAHsとハロゲン化PAHsだけではなく、その代謝物を含めて包括的な評価の基礎情報となる。