Treatment of spermatogenesis dysfunction by intratesticular drug administration using ISPS

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K20097
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 80030:Gender studies-related
• Research Institution: Okayama University
• Principal Investigator: Tominaga Yuusuke 岡山大学, 大学病院, 医員 (40865169)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 造精機能障害 / 男性不妊

Outline of Final Research Achievements

Various conditions were investigated for direct administration of the drug into the testis by ISPS (in situ permeation system) to diffuse and permeate the drug, and some results were obtained. In addition, in a form derived from this project, in order to allow the drug to reach the testicular parenchyma from outside the testis capsule through the capsule, a preliminary permeation experiment was conducted using a solvent that is said to have relatively strong tissue penetrating power. As the research, we conducted tissue penetration experiments of various drugs in various normal and abnormal tissues, and obtained findings in each experiment.

Free Research Field

泌尿器科

Academic Significance and Societal Importance of the Research Achievements

本研究の成果として、精巣組織内へISPSにより直接的に薬剤を注入投与する方法に加えて、精巣被膜外から被膜を通過して精巣実質へ薬剤を到達させる方法も精巣に対するドラッグデリバリーシステムとして有用である可能性が示唆された。今後において、精巣内細胞（精細胞、セルトリ細胞、間質細胞）を治療の対象として精子形成能を改善させるための治療法の開発や、造精機能障害研究における一つの解析基盤としてISPSの有用性が示唆された。