2022 Fiscal Year Final Research Report
Development of bone implant with power source from stacked hydrogels mimicking electric eel tissue
| Project/Area Number |
20K20175
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 積層ハイドロゲル電池 / 生体インプラント / CAD/CAM / 生体力学 / 生体材料学 |
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| Outline of Final Research Achievements |
The objectives of this research are to further increase the power output of the laminated hydrogel battery, which is novel worldwide, to elucidate its mechanical properties and biocompatibility, and to establish a design and development system for a new type of implant with an artificial power-generating organ based on the obtained indicators. During this research period, we established a fabrication method for laminated hydrogel batteries, further increase the power output, and elucidated the mechanical properties of the gel. The effects of electrical stimulation on cell proliferation and extracellular matrix formation by the bone implants with artificial power generating organs were investigated through the design and trial manufacture of bone implants using FEA (CT-FEA) based on CT images and cell culture experiments using osteoblast cells.
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| Free Research Field |
生体医工学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題で提案している積層ハイドロゲル電池の研究は国外を通しても極めて少なく，国内では皆無である．先行研究では，Schroederらが電気ウナギの発電組織を模擬し，それまでにない柔軟で生体適合性が期待できる電池を発表している．しかしながら，力学特性や生体適合性，電池としての機能についても明らかにされていない．それに対し，本研究課題では，先行研究と同等の電力特性を有するゲル電池の開発に成功し，力学特性と生体適合性についても詳細に解明している．さらにCT-FEAを用いた骨形成を促進する骨用インプラントの設計製造法の確立に取り組んでおり，国内外を通しても独創性は極めて高いと考える．
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