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2021 Fiscal Year Final Research Report

Elucidation of the mechanism of soft-domain-directed movement of cells induced by micro-topography of substrate surfaces

Research Project

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Project/Area Number 20K20183
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionKyushu University

Principal Investigator

Sasaki Saori  九州大学, 工学研究院, 助教 (20772320)

Project Period (FY) 2020-04-01 – 2022-03-31
Keywordsゼラチン / ハイドロゲル / リンクル構造
Outline of Final Research Achievements

It is still difficult to precisely control the surface micro-wrinkles of functional materials, especially biomimetic soft hydrogels. To solve this problem, we developed a two-step cross-linking method of gelatin sols with glutaraldehyde (GA). In this study, we developed a biomimetic platform by establishing a method to precisely control the multi-scale microporosity structures that spontaneously form on the gel surface. This study has developed a cell culture hydrogel that enables independent control of elastic modulus and microporosity structure, and can elucidate the mechanism of cell migration behavior to the surface microporosity structure.

Free Research Field

材料工学

Academic Significance and Societal Importance of the Research Achievements

細胞遊走は、恒常性の維持、様々な生理機能の発現や、組織・器官の発生において基礎をなす機能である。細胞外環境の特性が細胞の接着、伸展、増殖、分化などの特性に決定的な影響を与える。得られたゲルは表面微細凹凸構造への細胞遊走挙動を観察するプラットフォームとして期待できる。また、細胞形状が微細凹凸構造に応答していることが示されており、細胞操作材料としての応用も期待される。細胞の遊走について新たなメカニズムが提案されることは、細胞バイオメカニクス領域の発展に貢献できると考えられる。

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Published: 2023-01-30  

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