2022 Fiscal Year Annual Research Report
Design of degradable glycopolymeric nanoparticles for the safe and targeted delivery of proteins
| Project/Area Number |
20K20197
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
Rajan Robin 北陸先端科学技術大学院大学, 先端科学技術研究科, 助教 (70848043)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Protein Aggregation / Glycopolymers / Zwitterioinic polymers / RAFT Polymerization / hydrophobic interaction / biopharmaceutics / micelles / ultracentrifugation |
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| Outline of Annual Research Achievements |
Protein-based therapeutics face denaturation and aggregation issues during development and manufacturing, requiring isolation from stabilizing agents for effective creation, transportation, and storage. Simple, denaturation-free removal is critical. Self-assembled micelles protect proteins from stresses and can be easily separated via ultracentrifugation, stabilizing proteins while retaining their properties. This is the first study demonstrating a micellar system for protein stabilization, potentially enabling the development of off-the-shelf protein-based products that do not require low-temperature storage, and can be used for protein purification, processing, and recombinant protein production.
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Research Products
(7 results)
