2021 Fiscal Year Final Research Report
Design and Synthesis of Smart DDS Carrier from Peptide/Vinyl Polymer Hybrid Strategy
| Project/Area Number |
20K20201
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | ペプチドリガンド / ドラッグデリバリーシステム (DDS) / 高分子バイオマテリアル / がん細胞選択性 / 細胞取り込み / pH応答性 / 液液相分離 / 生体親和性 |
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| Outline of Final Research Achievements |
Chemotherapy is considered one of the most effective methods to systemically attack cancerous tissues in the whole body, even if the tumor is hidden and hardly visible.
However, anticancer drugs can also destroy normal cells and cause serious side effects, which result in significant deterioration of the quality of life for patients with cancer. It is known that the tumor microenvironment has a major characteristic such as an acidic extracellular pH of ~ 6.5 compared with normal tissues (pH ~ 7.4). In this study, a novel pH-sensitive peptide containing an RGD epitope was successfully developed and clarified the mechanism of internalization into cancer cells. This peptide was efficiently took in cancer cells compared with normal cells. In addition, a novel biocompatible polymer materials which occur liquid-liquid phase separation (LLPS) were also successfully developed. The polymer materials can be applied to drug delivery system carrier.
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| Free Research Field |
高分子化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果の学術的意義は、弱酸性雰囲気で急速な構造転移を起こすペプチドが、その高次構造変化に基づいてがん細胞選択的取り込みを達成した点にある。これは30残基程度の短いペプチドが、高次構造を適切に設計することで天然のタンパク質様の機能を発現できることを示唆している。この様なペプチドはがん細胞にのみ薬剤を輸送できるリガンド分子として高いポテンシャルを秘めており、社会が求めるがん細胞選択的DDSキャリアーの開発に大きく貢献する点で意義深い。
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