Development of immuno-suppressive scaffold for regenerative medicine

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K20207
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: National Institute for Materials Science
• Principal Investigator: NISHIGUCHI Akihiro 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主任研究員 (10784944)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 再生医療 / 組織再生 / 免疫制御 / ポリアミン / 足場材料 / 抗炎症

Outline of Final Research Achievements

In this study, we aimed to develop a regenerative scaffold that suppresses immune rejection of allogenic cells. Scaffolds made of polyamine and hyaluronic acid were fabricated and evaluated for their immunosuppressive function. The developed scaffold was found to possess high biocompatibility, scaffold function, and immunosuppressive functions. Moreover, we found that the scaffold functioned as a cell delivery carrier by encapsulating cells. This method would be useful for suppressing immune rejection in regenerative medicine and enhancing transplantation efficiency.

Free Research Field

バイオマテリアル

Academic Significance and Societal Importance of the Research Achievements

本研究は、再生医療を加速する基盤的な研究として、医療イノベーションを推進し、心不全や脊髄損傷、糖尿病などの難治性疾患治療や移植片対宿主病の予防に対する医療シーズの創出へと大きな波及効果をもたらすと期待される。他家細胞による再生医療は、生涯寿命・健康寿命の延伸に貢献し、2050年に約2.5兆円に達する再生医療市場の発展にも寄与する。