2020 Fiscal Year Research-status Report
Therapeutic polymer nanoreactor with site-specific activation of targeting Warburg metabolism for metastatic breast cancer treatment
| Project/Area Number |
20K20209
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
LI JUNJIE 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (80869892)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | immunotherapy / nanoreactors / pyroptosis / self-assembly / vesicles / tumor metabolism |
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| Outline of Annual Research Achievements |
1. We provided a general platform to engineer vesicular nanodevices with tunable permeability without trade-offs between structural integrity, flexibility, and functionality by integrating stimuli-responsive linkers into crosslinking membrane networks.
2. We found that glucose oxidase-loaded PICsomes could induce an immunostimulatory form of cell death (pyroptosis), which has the great potential for priming anti-tumor immunotherapy and opens new avenues for using GOD-loaded nanocarriers as a cancer treatment modality.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The method to engineer vesicular nanoreactor already has been confirmed. The in vitro proof-of-concept therapeutic investigation also has been proved.
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| Strategy for Future Research Activity |
1. Preparation of glucose oxidase and lactate oxidase co-loaded nanoreactor and in vitro therapeutic investigation.
2. In vivo therapeutic investigation.
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| Causes of Carryover |
Some ELISA kits arrived institute later. The remaining amount will be used to buy ELISA kits.
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