• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2021 Fiscal Year Research-status Report

Therapeutic polymer nanoreactor with site-specific activation of targeting Warburg metabolism for metastatic breast cancer treatment

Research Project

Project/Area Number 20K20209
Research InstitutionKawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine

Principal Investigator

LI JUNJIE  公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (80869892)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywordsimmunotherapy / nanoreactors / pyroptosis / self-assembly / vesicles / tumor metabolism
Outline of Annual Research Achievements

We developed a oxidase-loaded nanoreactor that could specifically render tumor cells immunogenic by pyroptosis, a highly pro-inflammatory programmed cell death. Of particular interest, the vesicular system based on PICsomes is highly modular, generic, and simple and could be adapted to customize various kinds of activatable nanoreactors based on triggerable cross-linking membrane networks. As a consequence, the nanoreactor with self-boosting catalytic glucose oxidation could protect oxidase to initiate pyroptosis in the long term. We confirmed that not only glucose oxidase-loaded but also lactate oxidase-loaded nanoreactors could induce pyroptosis.

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

1. We confirmed that the glucose and lactate could be simultaneously consumed by oxidase-loaded vesicular nanoreactor with accompanying ROS production, which aggravated nutrients metabolic stress to induce cancer cell death.
2. As a accident discovery, nanoreactors could induce an immunostimulatory form of cell death by pyroptosis, which has the great potential to prime anti-tumor immune responses.

Strategy for Future Research Activity

1. In vivo anti-tumor therapy is ongoing.
2. Combination therapy (nanoreactor plus anti-PD-1 immunotherapy) is also ongoing.

Causes of Carryover

Some reagents arrived later.

  • Research Products

    (5 results)

All 2022 2021

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results)

  • [Journal Article] Targeted nanomedicine in cisplatin-based cancer therapeutics2022

    • Author(s)
      Han Yu、Wen Panyue、Li Junjie、Kataoka Kazunori
    • Journal Title

      Journal of Controlled Release

      Volume: 345 Pages: 709~720

    • DOI

      10.1016/j.jconrel.2022.03.049

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effective mRNA Protection by Poly( <scp>l</scp> ‐ornithine) Synergizes with Endosomal Escape Functionality of a Charge‐Conversion Polymer toward Maximizing mRNA Introduction Efficiency2022

    • Author(s)
      Dirisala Anjaneyulu、Uchida Satoshi、Li Junjie、Van Guyse Joachim F. R.、Hayashi Kotaro、Vummaleti Sai V. C.、Kaur Sarandeep、Mochida Yuki、Fukushima Shigeto、Kataoka Kazunori
    • Journal Title

      Macromolecular Rapid Communications

      Volume: 2100754 Pages: 2100754~2100754

    • DOI

      10.1002/marc.202100754

    • Peer Reviewed
  • [Journal Article] Enzymatically Transformable Polymersome‐Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer2021

    • Author(s)
      Li Junjie、Ge Zhishen、Toh Kazuko、Liu Xueying、Dirisala Anjaneyulu、Ke Wendong、Wen Panyue、Zhou Hang、Wang Zheng、Xiao Shiyan、Van Guyse Joachim F. R.、Tockary Theofilus A.、Xie Jinbing、Gonzalez‐Carter Daniel、Kinoh Hiroaki、Uchida Satoshi、Anraku Yasutaka、Kataoka Kazunori
    • Journal Title

      Advanced Materials

      Volume: 33 Pages: 2105254~2105254

    • DOI

      10.1002/adma.202105254

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hypoxia-responsive block copolymer polyprodrugs for complementary photodynamic-chemotherapy2021

    • Author(s)
      Zhou Qinghao、Mohammed Fathelrahman、Wang Yuheng、Wang Jingbo、Lu Nannan、Li Junjie、Ge Zhishen
    • Journal Title

      Journal of Controlled Release

      Volume: 339 Pages: 130~142

    • DOI

      10.1016/j.jconrel.2021.09.023

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tumor-dilated polymersome nanofactories for enhanced enzyme prodrug chemo-immunotherapy2021

    • Author(s)
      Japir Abd Al-Wali Mohammed M.、Ke Wendong、Li Junjie、Mukerabigwi Jean Felix、Ibrahim Alhadi、Wang Yuheng、Li Xiang、Zhou Qinghao、Mohammed Fathelrahman、Ge Zhishen
    • Journal Title

      Journal of Controlled Release

      Volume: 339 Pages: 418~429

    • DOI

      10.1016/j.jconrel.2021.10.015

    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi