2022 Fiscal Year Annual Research Report
Therapeutic polymer nanoreactor with site-specific activation of targeting Warburg metabolism for metastatic breast cancer treatment
| Project/Area Number |
20K20209
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| Research Institution | Kyushu University |
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Principal Investigator |
LI JUNJIE 九州大学, 先導物質化学研究所, 准教授 (80869892)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Immunotherapy / Nanoreactors / Pyroptosis / Self-assembly / Vesicles / Tumor metabolism |
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| Outline of Annual Research Achievements |
We developed a oxidase-loaded nanoreactor that could specifically render tumor cells immunogenic by pyroptosis, a highly pro-inflammatory programmed cell death. Of particular interest, the vesicular system based on PICsomes is highly modular, generic, and simple and could be adapted to customize various kinds of activatable nanoreactors based on triggerable cross-linking membrane networks. As a consequence, the nanoreactor with self-boosting catalytic glucose oxidation could protect oxidase to initiate pyroptosis in the long term. We confirmed that not only glucose oxidase-loaded but also lactate oxidase-loaded nanoreactors could induce pyroptosis. In combination with immunotherapy, the antitumor efficacy has been confirmed.
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