Revealing the mechanism of atrial fibrosis in atrial fibrillation patients using an organo-culture system

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K20225
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Oita University
• Principal Investigator: Fukui Akira 大分大学, 医学部, 助教 (70631381)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 心房細動 / 心房線維化 / 心房低電位領域

Outline of Final Research Achievements

Although we started the analysis, there were no specific factor contributing with left atrial low voltage area (=atrial fibrosis) using the organo-culture system. Therefore, we examined the mitochondrial system of the right atrial human tissue using electronic microscope whether there is mitochondrial dysfunction in fibrotic atrium. However, there were no relation between atrial low voltage area and mitochondrial dysfunction. In conclusion, we failed to revealing a specific factor contributing in the pathogenesis of atrial fibrosis.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

研究結果より，線維化と相関する血液成分が多岐にわたることが判明し，左房の低電位領域は特定の成分や原因によらないことが明らかとなった．また、電子顕微鏡観察したヒト心房のミトコンドリア形態異常と左房低電位領域にも相関関係は認められなかった。
心房線維化の原因が多岐にわたることが原因と考えられた。ネガティブな結果であったが、この結果が今後の同分野の研究の参考となればと考えている。