2020 Fiscal Year Annual Research Report
Development of a dual-mode optical/microgravimetric biosensor for the detection of three prostate cancer biomarkers
| Project/Area Number |
20K20237
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
Funari Riccardo 沖縄科学技術大学院大学, マイクロ・バイオ・ナノ流体ユニット, 研究員 (20866058)
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| Project Period (FY) |
2020-04-01 – 2021-03-31
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| Keywords | Biosensor / Prostate cancer / SARS-CoV-2 |
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| Outline of Annual Research Achievements |
I was able to develop an opto-microfluidic sensing platform to detect specific biomarkers in human plasma. The ongoing global pandemic of SARS-CoV-2 motivated us to use this device to detect first COVID-19 related proteins such as anti-SARS-CoV-2 S antibodies (DOI: 10.1016/j.bios.2020.112578).
This device has been further developed to achieve the detection of multiple biomarkers in the same sample using a single integrated device, and is the subject of a recently submitted pubblication about COVID-19 reasarch and of a next paper on prostate cancer biomarkers detection in human plasma. Specifically, this biosensor allows to detect prostate specific antigen, matrix metalloproteinase-2 and anti-alpha-methylacyl-CoA in real sample with high sensitivity (LOD < 0.5 ng/mL) in less than 30 min.
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Research Products
(4 results)
