Application of computational origami to formulation of cells

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K20311
• Project/Area Number (Other): 17H06287 (2017-2019)
• Research Category: Grant-in-Aid for Challenging Research (Pioneering)
• Allocation Type: Multi-year Fund (2020); Single-year Grants (2017-2019)
• Research Field: Information science, computer engineering, and related fields
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: Uehara Ryuhei 北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (00256471)
• Co-Investigator(Kenkyū-buntansha): 堀山 貴史 北海道大学, 情報科学研究院, 教授 (60314530) ; 繁富 香織 北海道大学, 高等教育推進機構, 特任准教授 (90431816)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: バイオ折り紙 / 細胞折り紙 / 計算折り紙 / 展開図 / 多面体 / 高速列挙アルゴリズム / 空間充填立体

Outline of Final Research Achievements

The purpose of this research was to construct a theoretical model for the construction of the three-dimensional structure of small-sized cells through experiments using actual cell origami, and to evaluate the foldability for cells. Under some conditions, cell folding experiments were performed. Based on these experimental results, we devised some model candidates that give a valid "foldability index" considering physical constraints. We are currently verifying the validity between the experimental data and the theoretical model we devised, and are preparing to publish it as a paper in the future. Especially from the mathematical aspect, it is considered that the greatest significance of this research is that we were able to construct a theoretical model that incorporates physical constraints to some extent.

Free Research Field

理論計算機科学

Academic Significance and Societal Importance of the Research Achievements

例えば幹細胞では細胞の形状から機能分化が起こることが知られている．仮に幹細胞の形状を制御できれば狙った臓器を組織させることが可能となり，再生医療に大きなインパクトを与えられる．細胞折り紙は，目的とする形状の細胞の塊を直接構成することに比べて大きな優位性があると考えられるが，細胞にとって折りやすい展開図を与えることが求められる．結果的に理論的なモデルの構築と実験によるある程度の評価ができた．