Development of high-precision periodontal health examination using saliva

2020 Fiscal Year Final Research Report

• Project/Area Number: 20K20393
• Project/Area Number (Other): 18H05387 (2018-2019)
• Research Category: Grant-in-Aid for Challenging Research (Pioneering)
• Allocation Type: Multi-year Fund (2020); Single-year Grants (2018-2019)
• Review Section: Medium-sized Section 57:Oral science and related fields
• Research Institution: Osaka University
• Principal Investigator: Amano Atsuo 大阪大学, 歯学研究科, 教授 (50193024)
• Co-Investigator(Kenkyū-buntansha): 久保庭 雅恵 大阪大学, 歯学研究科, 准教授 (00303983) ; 坂中 哲人 大阪大学, 歯学研究科, 助教 (90815557)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: 歯周健康診査 / 唾液検査 / ポリアミン / バイオフィルム

Outline of Final Research Achievements

In this study, we proceeded to (1) identify a group of salivary metabolites that serve as biomarkers of periodontal disease severity and (2) identify a group of salivary metabolites that reflect disease trends in cardiometabolic diseases. As Firstly, cadaverine, a type of polyamine, showed a significant positive correlation with PISA, suggesting that this compound possesses properties as a robust marker of periodontal disease severity. Secondly, HbA1c and several monosaccharide analogs co-vary in both blood and saliva, and several amino acids co-vary in dyslipidemia.

Free Research Field

予防歯科学

Academic Significance and Societal Importance of the Research Achievements

唾液は最も採取しやすい生体試料のひとつであり、唾液を利用して手軽に口腔や全身の健康状態の評価が可能となれば、「患者自身も自分の健康度と疾患状態を知る主治医となる」ことを主軸とした次世代の健康増進医療の普及、さらには健康長寿社会の達成に向けた動きを加速させると考えられる。