Investigation of trans and cis-trans fatty acid concentrations in humans and foods, production mechanism, and health effects.

2020 Fiscal Year Final Research Report

• Project/Area Number: 20K20396
• Project/Area Number (Other): 18H05391 (2018-2019)
• Research Category: Grant-in-Aid for Challenging Research (Pioneering)
• Allocation Type: Multi-year Fund (2020); Single-year Grants (2018-2019)
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Setsunan University
• Principal Investigator: Ohta Souichi 摂南大学, 薬学部, 教授 (10213729)
• Co-Investigator(Kenkyū-buntansha): 杠 智博 摂南大学, 薬学部, 助教 (10783011) ; 中尾 晃幸 摂南大学, 薬学部, 准教授 (20288971)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: トランス型脂肪酸 / シス・トランス混合型脂肪酸 / 高精度定量 / GC/MS

Outline of Final Research Achievements

The outline of this research result is as follows: 1) Linoleic acid (n-6) -based and α-linolenic acid (n-3) -based trans-type and cis-trans-type mixed fatty acids synthesized by the principal investigators are standard products. As a result, we have achieved the establishment of a high-precision GC / MS fatty acid analysis method by introducing a new HPLC purification method by the recycle valve method using a linked silver ion column, and by making full use of the analysis method, 2) various By quantifying trans-type and cis-trans-type mixed fatty acids in human body samples (serum, breast milk) with high accuracy.
Finally, we were able to provide the relevant knowledge for "true" human health evaluation.

Free Research Field

食品衛生学、疾病予防学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義等や社会的意義は、我が国並びに諸外国の既存データ値の根拠に大きな一石を投ずる結果となりうること、またトランス体を含めたシス-トランス型必須脂肪酸が有する健康影響評価に資する有益な知見を提供することが可能となる。加えて、近年、増加傾向にある幼少期の肥満や生活習慣病の予防策、並びに未解明な種々の疾病の誘発因子の解明のための基礎的知見を提供することが可能であり、その社会的波及効果は極めて大きい。