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2022 Fiscal Year Final Research Report

Identification of new NAD+ metabolism pathway and its implication for anti-aging

Research Project

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Project/Area Number 20K20655
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Studies on the Super-Aging Society
Research InstitutionUniversity of Toyama

Principal Investigator

Nakagawa Takashi  富山大学, 学術研究部医学系, 教授 (40610374)

Project Period (FY) 2020-07-30 – 2023-03-31
KeywordsNAD+ / 老化 / 代謝
Outline of Final Research Achievements

Nicotinamide adenine dinucleotide (NAD+) is considered one of the regulators of aging, and NAD+ replacement using NAD+ precursors has attracted attention in recent years as an anti-aging therapy. We used nicotinamide riboside (NR), an NAD+ precursor of a nucleoside form, and analyzed the NAD+ synthesis pathways from NR in vivo. We revealed that BST1 (CD157), a paralog of CD38, has enzymatic activities of hydroxylation and base-exchange against NR. We further demonstrated that the intestinal microbiota and BST1 functions in a novel NAD+ synthesis pathway which links the amidated and deamidated pathways.

Free Research Field

薬理学、代謝学

Academic Significance and Societal Importance of the Research Achievements

NAD(ニコチンアミドアデニンジヌクレオチド)は老化制御因子の一つとして近年非常に注目を浴びている。NADの合成経路にはアミド体を介する経路と脱アミド体を介する経路があり,それらは独立してNAD合成を行っていると考えられていた。我々は、NAD前駆体としてヌクレオシド体であるニコチンアミドリボシド(NR)を用いて、生体内でのNRからNADの合成系について解析を行い、アミド体と脱アミド体をつなぐ新たな代謝経路を発見した。本成果はNAD前駆体を用いたNAD補充療法の発展に寄与するものであり、さらなる効率良い抗老化法確立に役立つと考えられる。

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Published: 2024-01-30  

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