2021 Fiscal Year Final Research Report
Formation of aligned nanofibers by combining ECF jet flow and electrospinning
| Project/Area Number |
20K20957
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 18:Mechanics of materials, production engineering, design engineering, and related fields
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KIM Joon-wan 東京工業大学, 科学技術創成研究院, 准教授 (40401517)
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| Co-Investigator(Kenkyū-buntansha) |
吉田 和弘 東京工業大学, 科学技術創成研究院, 教授 (00220632)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | 電界共役流体 / エレクトロスピニング |
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| Outline of Final Research Achievements |
Cells are often cultured into scaffolds capable of supporting three-dimensional tissue formation for medical purposes. Many researchers have developed scaffolds mimicking the extracellular matrix (ECM) of the native tissue by using nanofibers formed by electrospinning. In general, nanofibers by electrospinning have the characteristic of random orientation, so it is not adequate to culture the cells aligned in a specific direction. To overcome this limitation, we propose to form an aligned nanofiber membrane using a sharp-angled collector pair and its parallel movement. Using this method, we successfully achieved more uniform and aligned nanofiber membranes than the previous one formed by the parallel plate collector. For more precise control of orientation, we also propose to place auxiliary electrodes in addition to the sharp-angled collector. We develop an electrospinning system that enables the proposed method and verifies its effectiveness experimentally.
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| Free Research Field |
マイクロメカトロニクス
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，鋭角形状のコレクタと，補助電極の組み合わせにより，コレクタ間距離がセンチメートルオーダに増加した場合でも配向精度の高い均一な整列ナノファイバの膜を形成することができている．この手法は従来手法より大面積のECMのための足場を製造する手法として期待できる．また，可動式コレクタを用いることで，マイクロ流路中に多様な方向に配向された積層ナノファイバが形成できる．本研究は，これまでにない基礎的研究であるとともに実用化に向けての大きな研究計画であり，多様な細胞外マトリックス(ECM)とその応用分野でのブレークスルーが期待される．
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