2022 Fiscal Year Final Research Report
Demonstration of an integrated cell processing device that revolutionizes minimally invasive prenatal diagnosis
Project/Area Number |
20K21100
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 27:Chemical engineering and related fields
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Research Institution | Chiba University |
Principal Investigator |
SEKI Minoru 千葉大学, 大学院工学研究院, 教授 (80206622)
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Co-Investigator(Kenkyū-buntansha) |
山田 真澄 千葉大学, 大学院工学研究院, 准教授 (30546784)
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Project Period (FY) |
2020-07-30 – 2023-03-31
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Keywords | マイクロ流体デバイス / 医療診断 / 細胞分離 / 染色 / 出生前診断 |
Outline of Final Research Achievements |
We have developed microfluidic technologies that can potentially innovate the prenatal diagnosis using fetal-derived nucleated red blood cells (NRBCs). We attempted to realize new systems that are highly accurate, minimally invasive, automated, and rapid processing of cells. For this purpose, we proposed several types of microfluidic systems that can efficiently perform a series of operations such as "enrichment and selection," "visualization of intracellular molecules by multi-step chemical treatment," and "capture for optical analysis" of cells that exist only in extremely small numbers, and evaluated their performances.
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Free Research Field |
生物化学工学
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Academic Significance and Societal Importance of the Research Achievements |
胎児の染色体異常を,迅速かつ正確に検出するための「出生前診断技術」のニーズが飛躍的に高まっているが,母体血中にわずかに存在するNRBCを利用した診断手法は未だ発展の途上にある。NRBCのような極めて希少な細胞を診断に用いるためには,選抜から検出に至る一連の操作の効率を劇的に向上させる必要がある。そのような技術開発にチャレンジすることによって,最終的には出生前診断技術に革新をもたらす知見が得られるものと期待された。
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