2023 Fiscal Year Final Research Report
Functional particle generation process via micro multiphase flow traversal
| Project/Area Number |
20K21104
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 27:Chemical engineering and related fields
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Nisisako Takasi 東京工業大学, 科学技術創成研究院, 准教授 (10431983)
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| Project Period (FY) |
2020-07-30 – 2024-03-31
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| Keywords | マイクロナノシステム / マイクロフルイディクス |
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| Outline of Final Research Achievements |
This study proposed and demonstrated a new technology for forming multiphase parallel flows in a microchannel with regularly arranged pillars, enabling precise control of droplets and particles to prepare functional microparticles. Using a microfluidic device made of silicone resin with an array of pillars, we first confirmed the formation of calcium alginate gel particles by reacting sodium alginate solution droplets with calcium ions in the multiphase flow. Next, carboxyl-modified polystyrene beads were directed through the flow of a polyelectrolyte solution, and surface modification was verified through zeta potential measurements. Finally, we attempted to generate bilayer vesicles by traversing lipid-coated water-in-oil droplets across the oil-water interface, identifying challenges for future research.
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| Free Research Field |
マイクロフルイディクス
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題は，従来は主に医療・バイオ分野で各種生体粒子向けに研究されてきたマイクロ流路を用いた分離技術を，材料科学分野での機能性微粒子の新規精密調製技術に応用し，全く異なる学術分野・用途でのイノベーションを目指したものである．当該学術分野の形成・発展により，今後さまざまな新奇ナノ・マイクロ粒子材料の創出が期待される．
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