2021 Fiscal Year Final Research Report
Development of innovative bioreactor having omnidirectional contactless interface
| Project/Area Number |
20K21113
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 27:Chemical engineering and related fields
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹村 研治郎 慶應義塾大学, 理工学部(矢上), 教授 (90348821)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | 定在波 / 音響波 / 浮揚 / 非接触界面 / バイオリアクター / 超音波 / 無容器反応 / 音響放射圧 |
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| Outline of Final Research Achievements |
Based on levitation technique using an ultrasonic waves, we tried to implement a floating droplet as a chemical and biological reactor that handles chemical compounds and biological substances. The enzymatic reaction proceeded in the droplet trapped at a standing wave node of the ultrasonic wave, and plasmids was not disrupted by levitation; these results indicate that cells can live in the droplet. Furthermore, it was indicated that the levitated E. coli has proliferating ability, and the animal cells in which the extracellular matrix remained has accelerated the formation of cell mass.
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| Free Research Field |
音響浮揚ケミカルバイロジー
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| Academic Significance and Societal Importance of the Research Achievements |
この研究成果は、この浮揚システムが化学・生物系で初めての無容器反応システムとして活用できることを示している。この技術はSDGsに適合するとともに、宇宙空間などの微小重力環境での液体の振る舞いを地上で疑似的に再現できている。本研究で取り組む無容器反応技術は、化学・生物学研究環境における革新的な次世代リアクターとしての活用が期待出来ることがわかった。
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