2022 Fiscal Year Final Research Report
Developments of basic technologies for realizing in vivo micro-machines
| Project/Area Number |
20K21130
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 28:Nano/micro science and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2020-07-30 – 2023-03-31
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| Keywords | 光造形 / ２光子造形 / マイクロマシン / 生体適合性 |
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| Outline of Final Research Achievements |
In this study, we conducted research on microstructure modeling technology and its mechanical driving technology for the development of micro-machines that can be driven in vivo. As a microstructure modeling method, we developed a two-photon photopolymerization method that does not use polymerization initiators, and confirmed that microstructures can actually be formed using biocompatible materials. To understand the changes in material properties due to polymerization, changes in molecular structure, mechanical properties, and biocompatibility were experimentally confirmed. A driving method for the microstructures was developed using vibration added by sound waves and the mechanical properties dependent on the shape of the structure. Microstructures of different shapes showed different frequency dependence, indicating that the motion of microstructures can be controlled by sound waves.
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| Free Research Field |
ナノフォトニクス
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、光重合法により造形された微細構造を生体内で利用するための課題であった生体毒性の問題を、生体毒性を示す重合開始剤を用いない光造形法を開発することで、解決した。また、光重合前後における、生体材料の機械的、化学的特性の変化を定量的に計測できる造形分析装置を新たに開発することで、光重合法により造形される微細構造の特性を詳細に理解することが可能となった。ミクロ領域ではマクロ領域の材料の力学特性をそのまま適用できないため、その場での特性評価技術の開発は今後のマイクロマシン技術の発展に貢献できる成果である。
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