2022 Fiscal Year Research-status Report
生物応用に向けた常温・常圧・水中ではたらく合成分子モーターの設計と合成
| Project/Area Number |
20K21131
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
ラッペン ゲナエル 奈良先端科学技術大学院大学, 先端科学技術研究科, 教授 (60812576)
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| Co-Investigator(Kenkyū-buntansha) |
安原 主馬 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (90545716)
西野 智雄 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (60824878)
尾本 賢一郎 奈良先端科学技術大学院大学, 先端科学技術研究科, 特任助教 (40820056)
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| Project Period (FY) |
2020-07-30 – 2024-03-31
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| Keywords | Molecular motor / Amphiphile / fluorescent tag / single molecule / membrane insertion |
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| Outline of Annual Research Achievements |
The synthesis of the new target has been advanced with the formation of the amphiphilic molecular motor functionalized with a chemical tag. As tag, we developed the synthesis of a rhodamine fragment which is very classic to be observed by optical microscopes.
Now, just one chemical step is missing to connect the amphiphilic motor with long alkyl chains and the rhodamine fluorescent derivative needed to follow the molecule in the artificial membrane. The coupling was not efficient yet so new connection strategies will be pursued in the next year.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
The project has been slowed down due to the COVID-19 sanitary crisis but we plan to finish the synthesis of the final compound as soon as possible before testing its integration in artificial membranes hopefully in the middle of the next year.
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| Strategy for Future Research Activity |
The synthesis of the target is not finished yet. We need to pursue our effort in its synthesis and characterization. After the synthesis will be achieved, the targeted amphiphilic motor will be fully characterized, including the absorption and emission properties necessary for its detection inside of an artificial membrane.
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| Causes of Carryover |
Due to the covid-19 sanitary crisis, some students were not able to join us on time and some compounds necessary for our research have not been available for many months. This slowed down our research with an impact on the end of this project. In the next year, some consumables including chemicals, glassware, plasticwares will be purchased to promote the research project.
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