Development of multichannel Ultrasensitive oscillator biosensor using graphite nano-thin film oscillators

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21144
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 29:Applied condensed matter physics and related fields
• Research Institution: Osaka University
• Principal Investigator: Ogi Hirotsugu 大阪大学, 工学研究科, 教授 (90252626)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: バイオセンサー / 振動子 / 多層グラフェン / ピコ秒超音波

Outline of Final Research Achievements

The oscillator biosensor is a typical label-free biosensor that allows a short measurement time and the evaluation of binding affinity between biomolecules, which is necessary for the drug discovery process. The sensitivity of such a sensor dramatically increases with the decrease in the mass density of the oscillator material and the decrease in the oscillator thickness, making the multilayer graphene nanofilm the most promising sensor material among all possible materials. In this study, we succeeded in developing a multichannel freestanding membrane oscillator based on extremely high-quality multilayer graphene nanofilms, and bioassays in the ultrahigh-frequency region with resonance frequencies exceeding 40 GHz were successfully performed. As a result, we succeeded in developing a sensor system whose detection sensitivity greatly exceeds that of conventional biosensors.

Free Research Field

超音波工学

Academic Significance and Societal Importance of the Research Achievements

安心・安全な社会の構築において、高感度かつハイスループットのセンサーシステムの確立は重要な課題である。本研究において開発するバイオセンサーシステムは、原理的には極めた高い感度のバイオアッセイを可能とし、早期診断や創薬プロセスにおいて多大に貢献する可能性を有する。