2021 Fiscal Year Final Research Report
Induction of artificial hibernation for medical application of characteristics of hibernators
| Project/Area Number |
20K21366
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 42:Veterinary medical science, animal science, and related fields
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
椎名 貴彦 岐阜大学, 応用生物科学部, 准教授 (90362178)
海野 年弘 岐阜大学, 応用生物科学部, 教授 (90252121)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | 冬眠 / 人工冬眠 / 低体温 / 低温ショックタンパク質 |
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| Outline of Final Research Achievements |
The purpose of this study was to induce artificial hibernation in animals that do not hibernate. When rats and mice were cooled under isoflurane anesthesia, they become hibernation-like hypothermia. Importantly, they can recover from the hypothermia to normal body temperature. Electrocardiogram and blood biochemical examination revealed that hypothermia induced by cooling under isoflurane anesthesia causes severe injury. Next, we examined a mechanism to protect biological functions under the severe hypothermic condition. Experiments focusing on the gene expression of cold-inducible RNA-binding protein (CIRP), which has a cytoprotective effect, revealed that regulation of functional CIRP expression at the level of splicing is important to avoid harmful low temperature not only in hibernators but also in non-hibernators.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
冬眠中の動物には、虚血性傷害がない、骨格筋の萎縮がない、感染に耐性がある、放射線に耐性がある、寿命が延長する、等の驚異的な特徴が知られている。これらの特徴を冬眠しない動物で再現できれば、ヒトや伴侶動物の医療に大きな変革をもたらすことが期待できるが、冬眠しない動物に極度の低体温を誘発できないことが課題であった。冬眠動物ではないラットとマウスにおいて、冬眠様の低体温に誘導し、健常な状態で回復させることに成功した本研究の成果は、冬眠の性質を医療応用するための第一段階として、極めて意義深いものである。
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