2022 Fiscal Year Final Research Report
H. pylori-related microorganisms dominantly found in the coelomic fluids of marine invertebrates: understanding of their functions through transplantation experiments.
Project/Area Number |
20K21447
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2020-07-30 – 2023-03-31
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Keywords | 共生 |
Outline of Final Research Achievements |
Contrary to the widespread belief that "animal's coelomic fluids are sterile," we have found that the coelomic fluids of marine invertebrates contain more than 10,000 cells/ml of prokaryotes. These are unique microbial species not present in the surrounding environments or digestive tract. In this study, we analyzed the microbial community structure, host mortality, behavior (food intake), transcriptomes, and metabolites in the starfish. Our bacterial transplantation experiments supported the hypothesis that some of the starfish's ability to tolerate environmental stress is related to specific microorganisms in their coelomic fluids.
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Free Research Field |
微生物生態学
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Academic Significance and Societal Importance of the Research Achievements |
ヒトデは「海のギャング」と呼ばれ、その莫大な食害や駆除・廃棄コストやは全国の水産業喫緊の課題である。ヒトデの環境ストレス耐性と体腔液に特異的に棲息する微生物の関係についての新知見を得た本研究は、ヒトデ類の画期的対策や生理活性物質の利活用法を創出し、水産業の持続的発展に益するものと位置づけられる。加えて、ヒトデの体腔液に優占する特異微生物がヒトの病原菌と近縁であることは、安全・安心な水産資源の持続的生産にむけた対策の必要性を示唆するが、本研究はその礎となり得るものである。
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