Establishment of autophagy-inducing system to degrade RNA foci

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21521
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 49:Pathology, infection/immunology, and related fields
• Research Institution: Niigata University
• Principal Investigator: Inoue Keiichi 新潟大学, 医歯学系, 特任助教 (30396981)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: オートファジー / RNA foci / 神経変性疾患

Outline of Final Research Achievements

ALS and FTD are progressive and fatal neurodegenerative diseases, and many researchers and pharmaceutical companies have tried to develop treatments for them, but there is currently no effective treatment. The applicant was able to devise and construct two gene plasmid systems for treating these diseases. Currently, the effects are being investigated using various pathological model cells and animals.

Free Research Field

病態医化学

Academic Significance and Societal Importance of the Research Achievements

ALSやFTDは進行性・致死性の神経変性疾患で、これまで多くの研究者・製薬企業がその治療法の開発に挑んできたが、現在のところ有効な治療法がない。申請者は、本研究において、これらの疾患を治療するための２種類の遺伝子プラスミドシステムを構築することができた。今後、これらを実際の患者や患者由来組織に導入し、期待される効果が得られるか検討する必要がある。