2021 Fiscal Year Final Research Report
Dissecting molecular mechanism of diapause egg formation in dengue vector mosquito
| Project/Area Number |
20K21532
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Medium-sized Section 49:Pathology, infection/immunology, and related fields
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
高柳 咲乃 東京慈恵会医科大学, 医学部, 助教 (10794266)
|
|---|
| Project Period (FY) |
2020-07-30 – 2022-03-31
|
| Keywords | 越冬 / 蚊 / 越冬卵 / ヤブカ / ヒトスジシマカ |
|---|
| Outline of Final Research Achievements |
Temperate strains of Aedes albopictus that inhabit warmer regions can form overwintering eggs. On the other hand, tropical strains inhabiting Southeast Asia cannot produce overwintering eggs. In this research project, the molecular mechanisms underlying the overwintering strategy of Aedes albopictus were analyzed by RNAseq and genome editing by comparing temperate and tropical strains, which have different genetic backgrounds. The results suggest circadian rhythm-regulated genes, desiccation-related genes, and neuropeptide genes may be involved in overwintering egg formation.
|
| Free Research Field |
衛生動物学
|
| Academic Significance and Societal Importance of the Research Achievements |
越冬戦略は、生物のニッチ獲得に非常に重要である。哺乳類の冬眠も含めて、生物の越冬についての研究は途上である。研究代表者らの研究を通して、ヒトスジシマカの越冬戦略を遺伝子レベルで解明することは、生物一般の越冬メカニズムを理解するための突破口となることが期待される。加えて、越冬卵形成に関与する分子を標的にした越冬阻害剤の開発等、従来とは異なる病原体媒介蚊制御のための基盤となる可能性がある。
|
