Intervention of retinal diseases using energy metabolism reprogramming

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21642
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
• Research Institution: Tohoku University
• Principal Investigator: ABE Toshiaki 東北大学, 医学系研究科, 教授 (90191858)
• Co-Investigator(Kenkyū-buntansha): 大学 玲子 東北大学, 医学系研究科, 学術研究員 (10770604)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: HMGN1 / 網膜色素上皮

Outline of Final Research Achievements

We analyzed the nucleoprotein HMGN1 involved in metabolism in order to engage in regeneration using cell function regulation. We proceeded with the analysis by producing HMGN1-deficient cells and mating KO mice with other genetically modified mice. A new function of HMGN1 involved in metabolism was clarified, and the metabolism of the cells changed not only by localization but also by the expression level, and the expression change due to aging was also considered. It was also found that these are important changes related to retinal function as well as changes in cell metabolism. Although the original purpose could not be achieved within the period, a very important relationship between retinal function and metabolism was found.

Free Research Field

眼科

Academic Significance and Societal Importance of the Research Achievements

失明疾患は網膜疾患が多いが、なかでも視細胞障害は治療が難しい。今回は視細胞の再生をめざすために、代謝に関わる分子の発現を調節することを試みた。核蛋白質HMGN1に注目したが、この検討過程で網膜代謝に関わる非常に重要な結果を得ることができた。期間内に目的は達成できなかったが、これまでの結果は、今回の目的を達成するのに重要な結果を示してくれたと考えられるので、今後のさらなる研究を推し進めたい。