2021 Fiscal Year Final Research Report
Assessment of epigenome changes in fetal chemical exposure
| Project/Area Number |
20K21707
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | University of Yamanashi |
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Principal Investigator |
Miyake Kunio 山梨大学, 大学院総合研究部, 准教授 (60550712)
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| Co-Investigator(Kenkyū-buntansha) |
幸田 尚 山梨大学, 大学院総合研究部, 教授 (60211893)
宮下 ちひろ 北海道大学, 環境健康科学研究教育センター, 特任教授 (70632389)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | エピジェネティクス / 出生コホート / DNAメチル化 / ADHD / DOHaD |
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| Outline of Final Research Achievements |
The concept of Developmental Origins of Health and Disease (DOHaD) has been established that various environmental factors in the fetal period and infancy affect future health and the risk of developing diseases. TThe purpose of this study was to analyze DNA methylation and hydroxymethylation changes affected by cigarette smoke exposure and to clarify their involvement in the development of children. As a result, there were significant changes in cord blood DNA with maternal smoking exposure during pregnancy and DNA methylation of the five genes, but no association with DNA hydroxymethylation.
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| Free Research Field |
エピジェネティクス
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| Academic Significance and Societal Importance of the Research Achievements |
胎児期や乳幼児期の劣悪な環境（低栄養、ストレス、喫煙曝露など）は成長後のさまざまな疾患（糖尿病、アレルギー、神経発達障害など）のリスクを増加させる。本研究では、妊婦中の母親の喫煙はDNAメチル化を変化させ、子供の神経発達障害リスクの増加と関与することがわかった。したがって妊娠初期からの環境は子どもの将来の疾患リスクに影響することを科学的エビデンスに基づいて証明できたことは学術的、社会的意義は大きい。
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