New roles of bone tissue in the maintenance of homeostasis.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21762
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kumamoto University
• Principal Investigator: Yoshizawa Tatsuya 熊本大学, 大学院生命科学研究部(医), 准教授 (40313530)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: 骨組織 / ホルモン / 臓器連関

Outline of Final Research Achievements

We discovered that the osteoblastic SIRT7, which is the member of Sirtuins (SIRT1-7 in mammals) regulating a wide variety of biological process, can modulate the progression of hepatic tumor, glucose metabolism, and gut microbiota. Furthermore, we found the candidate gene of new bone-derived hormone which is predominately expressed in bone, and are now generating the osteoblast-specific knockout mice for this gene. These mice will be valuable to establish the new bone-derived hormone.

Free Research Field

骨代謝

Academic Significance and Societal Importance of the Research Achievements

近年、骨組織がホルモンを分泌し、様々な生体機能を調節していることが徐々に明らかとなってきた。我々は骨組織による新たな生体機能調節能の発見、およびその分子機構の解明を目指している。我々が挑戦している新たな骨ホルモンの発見は、生命現象の根幹に関わる研究であり生物学的に非常に大きな意義を持つばかりか、今後、骨組織が他臓器の疾患の治療標的となることが期待される。