Devising and implementing a new method to assess mitochondrial function in skeletal muscle: toward understanding heterogeneity and diversity.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K21771
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Nippon Sport Science University
• Principal Investigator: Tamura Yuki 日本体育大学, 体育学部, 准教授 (20794978)
• Project Period (FY): 2020-07-30 – 2023-03-31
• Keywords: ミトコンドリア / 骨格筋

Outline of Final Research Achievements

In order to achieve more effective treatment of skeletal muscle atrophy and metabolic diseases, it is necessary to accurately measure the mitochondrial function in skeletal muscle. However, conventional methods for mitochondrial analysis have been based on homogeneous solution of mitochondria in skeletal muscle, and mitochondrial heterogeneity and diversity could not be evaluated. In this study, we developed a new method to evaluate the ATP-producing capacity of skeletal muscle mitochondria while preserving mitochondrial spatial informatics.

Free Research Field

分子運動生理学

Academic Significance and Societal Importance of the Research Achievements

本研究により、空間情報を保持しながら骨格筋のミトコンドリアの機能を評価できる手法が開発されたことにより、微小であるが重要なミトコンドリアの機能的変化を評価できるようになった。このような技術は、骨格筋に関わる病態の一層の理解や治療法やリハビリテーションの開発に寄与することが期待される。