Design and construction of neutrophil-mediated drug delivery system

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21905
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: University of Shizuoka
• Principal Investigator: Asai Tomohiro 静岡県立大学, 薬学部, 教授 (00381731)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: drug delivery system / マイクロディスク / 好中球 / 炎症 / 脳梗塞

Outline of Final Research Achievements

In this study, a neutrophil-mediated drug delivery system (DDS) was designed and constructed for the purpose of ischemic stroke treatment. We prepared a micro disk composed of poly(lactic-co-glycolic acid) (PLGA) and modified neutrophils with the disk. The results of transwell assay indicated that the disk modification hardly affect the migration ability of neutrophils. When the disk-modified neutrophils were intravenously injected into inflammation model mice, they accumulated in the area of inflammation. Our results suggest that neutrophil-mediated DDS technology might be useful for the treatment of diseases with inflammation.

Free Research Field

薬物送達学

Academic Significance and Societal Importance of the Research Achievements

生細胞を薬物担体として用いるDDSに関する基盤研究は、これまでにない斬新なDDS医薬の創製に貢献するものであり、さらには細胞医薬の効果を高めるための研究の発展に繋がるであろうと期待される。Neutrophil-mediated DDS technologyの開発と治療応用に関する本研究は、細胞医薬が拓く未来の医療のさらにその先を見据えた挑戦的な取り組みであるといえる。