2021 Fiscal Year Final Research Report
Development of cancer therapies using tumor-accumulating electron-shuttling polymers
| Project/Area Number |
20K22465
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0401:Materials engineering, chemical engineering, and related fields
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | がん治療 / リン脂質ポリマー / 電子移動 / 酸化ストレス / がん免疫 |
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| Outline of Final Research Achievements |
We aimed to develop a novel cancer therapy using electron-shuttling polymers with cell membrane permeability. It was shown that the electron extraction from the mouse colon cancer CT26 cells by the polymers induced cell death through oxidative stress. Moreover, the release of a group of molecular patterns that activate immunity against cancer cells was observed in the group subjected to electron extraction via the polymers. The tumor formation was inhibited in mice injected with CT26 cells treated with electron extraction. These results indicate that the electron-shuttling polymers induced immunogenic cell death in CT26 cells and activated anti-tumor immunity.
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| Free Research Field |
ポリマーバイオマテリアル
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、電子輸送ポリマーを介した細胞内からの電子引き抜きによりがん細胞死を誘導する手法を構築し、電子輸送ポリマーががん細胞に対する免疫を誘導する形で細胞を殺傷していることを明らかにした。がん細胞に対する免疫の賦活化は、生き残ったがん細胞の根絶や転移がんを抑制するといった観点からも望ましい。また、電子輸送ポリマーに対する機能性ユニットの導入など、ポリマー分子設計に基づくさらなる治療効果向上が可能だと考えられ、新たながん治療法の創出が期待される。
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