Visualization of the pulsation of cerebral artery aneurysms with ultra-high field (7T) MRI

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22498
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Kyoto University
• Principal Investigator: Akasaka Thai 京都大学, 医学研究科, 特定助教 (00883224)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 7T MRI / 脳動脈瘤 / 拍動 / GRASP

Outline of Final Research Achievements

The purpose of this study was to establish the basis for developing a method that can depict and quantitatively evaluate the pulsations of cerebral aneurysms using 7T MRI. We successfully created a pulsating phantom, developed a pulse sequence program (radial 3D T1-weighted image) for 7T MRI and improved the reconstruction program (GRASP) for the purpose of this study, and verified the method by scanning the phantom on a 7T MRI scanner. The pulsating pseudoaneurysm was stable for a long time, beating at an arbitrary pulse rate with up to 2 mm of wall movement. The pulsation was depicted as a 3D movie at an arbitrary spacial resolution and temporal resolution.

Free Research Field

画像診断学

Academic Significance and Societal Importance of the Research Achievements

脳動脈瘤の破裂は未だに予後不良な重篤な疾患である。研究代表者の知る限り、壁運動を伴う疑似脳動脈瘤の拍動ファントムは現存せず、ラジアルスキャンと圧縮センシングの技術を用いたGRASPと呼ばれる最新の撮像法を改良して7T MRI上で拍動ファントムを撮像し得たことは、脳動脈瘤の拍動の描出および破裂率を正確に予測する上での重要な一歩であると考える。