2021 Fiscal Year Annual Research Report
A Combinatorial Approach Towards Multimetallic Artificial Receptors for Cancer-Related Biomarkers
| Project/Area Number |
20K22552
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
CATTI LORENZO 東京工業大学, 科学技術創成研究院, 助教 (50873478)
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | Molecular building block / Bromo-bissalicylaldehyde / Aqueous bioreceptor / Metal complex |
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| Outline of Annual Research Achievements |
The research led to the preparation of a new bromo-bissalicylaldehyde building block, which can be coupled to boronic acids/esters via standard Suzuki coupling conditions. Its attachment to metal complexes could in principle lead to new metal receptors for biomolecules in water using biomolecule-metal interactions. The advantage of the salicylaldehyde units over conventional aldehyde units is their increased stability against oxidation. The gained knowledge was utilized for the preparation of a review on artificial bioreceptors.
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