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2021 Fiscal Year Final Research Report

A Combinatorial Approach Towards Multimetallic Artificial Receptors for Cancer-Related Biomarkers

Research Project

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Project/Area Number 20K22552
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0502:Inorganic/coordination chemistry, analytical chemistry, inorganic materials chemistry, energy-related chemistry, and related fields
Research InstitutionTokyo Institute of Technology (2021)
Kanazawa University (2020)

Principal Investigator

Catti Lorenzo  東京工業大学, 科学技術創成研究院, 助教 (50873478)

Project Period (FY) 2020-09-11 – 2022-03-31
KeywordsArtificial Bioreceptor / Molecular building block / Metal Complex
Outline of Final Research Achievements

The research led to the preparation of a new bromo-bissalicylaldehyde building block, which can be coupled to boronic acids/esters via standard Suzuki coupling conditions. Its attachment to metal complexes has not been performed yet, but could in principle lead to new metal receptors for biomolecules in water using biomolecule-metal interactions. Using the salicylaldehyde units, I plan to vary the second coordination sphere of the receptor in the future via dynamic covalent chemistry to tune its selectivity. The advantage of the salicylaldehyde units over conventional aldehyde units is their increased stability in aqueous media against oxidation.

Free Research Field

Supramolecular Chemistry

Academic Significance and Societal Importance of the Research Achievements

Artificial bioreceptors are important for the detection of diseases via recognition of disease-related biomarkers. Previous receptors required long and difficult synthetic protocols. The herein attempted strategy aims to give simple access to a receptor framework whose target can be tuned on demand.

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Published: 2023-01-30  

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