2022 Fiscal Year Annual Research Report
Defining the mechanism of epidermal stem cell heterogeneity in skin aging
| Project/Area Number |
20K22659
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Raja Erna 筑波大学, 生存ダイナミクス研究センター, 助教 (30770581)
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| Project Period (FY) |
2020-09-11 – 2023-03-31
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| Keywords | epidermal stem cells / fibulin 7 / ECM / skin aging |
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| Outline of Annual Research Achievements |
By long term lineage tracing, we found that the fast-cycling epidermal stem cells are depleted during chronological skin aging while the slow-cycling counterparts are maintained. Interestingly, fibulin 7 ECM expression which is localized to the epidermal basement membrane, is reduced in aged skin. Mice lacking fibulin 7 expression exhibited early skin aging-like traits such as loss of fast-cycling stem cells, alterations in basement membrane-associated proteins such as Collagen IV, laminins and Collagen XVII, and aberrant differentiation state. Mechanistically, fibulin 7 keeps a slower epidermal stem cell proliferation in the young adult skin and this may contribute to minimize the accumulation of replication stress and early stem cell depletion.
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[Journal Article] The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging.2022
Author(s)
Raja, E., Changarathil, G., Oinam, L., Tsunezumi, J., Ngo, Y. X., Ishii, R., Sasaki, T., Imanaka-Yoshida, K., Yanagisawa, H., & Sada, A.
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Journal Title
EMBO reports
Volume: 23(12)
Pages: e55478
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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