2021 Fiscal Year Final Research Report
Association of blood-derived alpha-synuclein seeds with PD pathology
| Project/Area Number |
20K22693
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | パーキンソン病 / α-シヌクレイン / RT-QuIC / 全身臓器 / リポポリサッカライド |
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| Outline of Final Research Achievements |
We prepared homogenates of autopsy specimens in Parkinson's disease (PD) and analyzed α-synuclein seeds in each organ using the RT-QuIC method. We found that seeds were amplified in brain, submandibular gland, liver, kidney, heart, thyroid gland, and other systemic organs. This result confirms that structurally aberrant α-synuclein (AS) is distributed throughout the body. Furthermore, lipopolysaccharide levels were elevated in the appendix of PD compared to controls, suggesting the involvement of inflammation in AS aggregation.
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| Free Research Field |
神経内科学
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| Academic Significance and Societal Importance of the Research Achievements |
血液を循環する凝集する傾向を有したα-シヌクレイン(AS)を確認した。ASが全身臓器に蓄積しているという知見からパーキンソン病は全身病であることを裏付けることができた。これはPD病態が脳のみでなく全身の多起源説を想起させるものであり、さらには腸管炎症がAS凝集と関与している可能性も示された。今後、病態のモニタリングや治療ターゲットの探索、血液浄化療法など疾患修飾療法の礎となる結果であると考える。
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