2021 Fiscal Year Annual Research Report
敗血症におけるオレキシンの血液-脳脊髄液の液性システムダイナミクスの解明
| Project/Area Number |
20K22731
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| Research Institution | University of Tsukuba |
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Principal Investigator |
小川 靖裕 筑波大学, 附属病院, 医員 (20445406)
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | オレキシン |
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| Outline of Annual Research Achievements |
Her CSF could be safely sampled because she had a VP shunt, although it is ethically difficult to sample CSF routinely from patients with sepsis. Reduced CSF orexin levels gradually recovered as she recovered from sepsis. Unexpectedly, orexin was detected in the blood, which is unusual in healthy humans. Blood orexin was not detected after recovery from sepsis. This result may imply that orexin leaks into the blood because of BBB dysfunction. To the best of our knowledge, this is the first report investigating orexin levels in the CSF and blood of a patient with sepsis, and the data obtained from this case may provide a new understanding of the pathophysiology of SAE.
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