2021 Fiscal Year Final Research Report
The enhancement of anti-tumor activity by removal of senescent T cells
Project/Area Number |
20K22766
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0803:Pathology, infection/immunology, and related fields
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Research Institution | Ehime University |
Principal Investigator |
Matsuoka Yuko 愛媛大学, 医学部附属病院, 助教 (10879711)
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Project Period (FY) |
2020-09-11 – 2022-03-31
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Keywords | T細胞 / 養子免疫療法 / T細胞老化 |
Outline of Final Research Achievements |
Chimeric antigen receptor T-cell therapy is the most remarkable cancer treatment. However, there are many problems that need to be solved. One of them is the T cell senescence. During in vivo transplantation, Senescent T cells interfere with sufficient anti-tumor activity. In this study, we attempted to establish a method to enhance the anti-tumor activity of removal senescent T cells by targeting Gfi1, which is involved in the survival of senescent T cells. However, suppression of Gfi1 expression tended to decrease antitumor activity. Therefore, removal of senescent T cells targeting Gfi1 did not enhance anti tumor activity.
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Free Research Field |
免疫学
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Academic Significance and Societal Importance of the Research Achievements |
申請者の所属する研究室ではこれまでに転写抑制因子Gfi1が老化T細胞の生存に必須であることを見出しているが、本研究遂行により新たにGfi1が腫瘍局所のようなIL-2非存在下、もしくは低濃度条件下において、老化T細胞以外のT細胞の生存にも関与していることを明らかにした。
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