Development of a new radiation therapy for intractable tumors using microbeam X-rays

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22812
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: Kobe University
• Principal Investigator: Emoto Yuki 神戸大学, 医学部附属病院, 特命技術員 (10882863)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: FLASH照射 / マイクロビーム / 放射光

Outline of Final Research Achievements

Purpose: Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in short period of time with a single fraction using arrays of micro-slit beam radiation therapy. Methods: Synchrotron X-ray beam radiation was performed using BL28B2 beam-line at the SPring-8 facility, Hyogo, Japan. The animals used were male DBA/2 mice aged 13-15 weeks old, inoculated KLN205 2.5 x 10^6 cells/mouse 4 weeks before the exposure of the beam. Delivered dose of the broad beam was 36 Gy while that of the MRT were 36-120 Gy. Results: According to microscopic observations, the areas of tumor on the slides were reduced to one-third compared to the unirradiated region in the slides of 120 Gy MRT while the total lung area was not collapsed and maintained its original size. Conclusions: Such high doses of MRT can diminish the tumor volumes without breaching of lung tissue scaffoldings. There is a good possibility that MRT would control the growth of metastatic lung tumors.

Free Research Field

放射線治療

Academic Significance and Societal Importance of the Research Achievements

がんは2人に一人が罹患する疾患であるが、根治できない症例があるのも事実である。手術療法や抗がん剤など種々の治療が行われるが放射線治療もそのひとつであり、放射線治療では根治できない癌種も少なからず存在する。その難治性病変に対して新たな放射線治療法を提案しその効果や安全性を評価していく。
新たな放射線治療法が確立されれば現在の医学では根治できないがん病変に対して根治できる可能性が広がり大変有用である。