2021 Fiscal Year Final Research Report
Elucidation of the mechanism of gastric cancer progression and development of innovative therapeutic strategies focusing on cell adhesion molecules
| Project/Area Number |
20K22831
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0901:Oncology and related fields
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | 胃癌 / コネキシン26（Cx26) / 腸型胃癌 / β-catenin |
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| Outline of Final Research Achievements |
In this study, high cytoplasmic Cx26 expression was associated with favorable prognosis in intestinal- and mix-type gastric cancer and could be an independent prognostic factor for overall survival. In terms of the mechanism, in in vitro experiments changes in Cx26 localization to the cytoplasm were shown to suppress the change of localization of β-catenin to the nucleus by binding to it in the cytoplasm. Cytoplasmic Cx26 was found to be a prognostic factor in intestinal- and mix-type gastric cancer. Regarding the mechanism, in vitro studies revealed that cyto plasmic Cx26 inhibits the translocation of β-catenin to the nucleus.
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| Free Research Field |
消化管外科
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| Academic Significance and Societal Importance of the Research Achievements |
乳癌、大腸癌、肺癌、膵癌や、われわれが以前に報告した食道扁平上皮癌において、細胞質でのCx26発現が予後や遠隔転移に関与しているなどの報告がある。胃癌においては癌化に伴うCx26の細胞膜から細胞質内への局在変化や、細胞質におけるCx26の機能的意義についてはほとんど明らかにされていなかった。今回Intestinal and mix typeの胃癌において、本来細胞膜に位置するCx26が癌化の過程で細胞質に局在変化を起こし、β-cateninの核内移行を抑制することを証明し、治療予後との相関も示した。今後胃癌においてCxをターゲットとした全く新たな治療戦略の開発を目指せる可能性が考えられた。
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