Identification of Dormant Cells in Ewing sarcoma

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22847
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: Kobe University
• Principal Investigator: Takemori Toshiyuki 神戸大学, 医学部附属病院, 医員 (20884456)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: Dormant cell / Ewing肉腫 / Tet on system

Outline of Final Research Achievements

The mechanical of local recurrence and distant metastases of cancer remains unclear. Recently, dormant cell, which is a very small population, has been suggested to be involved in local recurrence and distant metastasis of cancer, but there are no reports of dormant cell in Ewing's sarcoma. We have demonstrated that cells identified and isolated from existing Ewing's sarcoma cell lines using the Tet on system have the characteristics of dormant cells with low proliferative capacity and resistance to anticancer drugs.

Free Research Field

腫瘍学およびその関連分野

Academic Significance and Societal Importance of the Research Achievements

がんの治療成績は向上しているものの、再発・転移はいまだ制御困難であり、再発・転移のメカニズムはいまだ不明な点が多い。様々ながん種でdormant cellの関与が示唆されているが、希少かつ治療困難であるEwing肉腫におけるdormant cellの報告はない。dormant cellは少数の細胞集団でありかつ、骨軟部腫瘍そのものが希少であることから、dormant cellが既存の細胞株から新たなTet on systemを用いて同定・分離可能となったことで、量的制約を解消でき、このdormant cellの特性を探索することで再発・転移のメカニズムの解明につながることが期待できる。