The mechanisms of carcinogenesis of the novel cancer-related gene PBK / TOPK in gastrointestinal cancer and its clinical application

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22853
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Ohashi Takuma 京都府立医科大学, 医学部附属病院, 専攻医 (50888005)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 膵癌 / PBK/TOPK

Outline of Final Research Achievements

Regarding the elucidation of the PBK / TOPK molecular mechanism of pancreatic cancer, we analyzed the correlation between TP53 status and PBK / TOPK in pancreatic cancer samples. No significant correlation could be identified.　Regarding the regulatory molecular mechanism of tumor suppressor microRNA, we examined the relationship between microRNA including miR-216b and PBK / TOPK in pancreatic cancer samples. No candidate microRNA could be identified.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

PBK/TOPKは本邦で阻害剤の開発が進む極めて有望な治療法的分子であり、難治癌である膵癌の新規の癌関連遺伝子、治療標的分子となる可能性がある。本研究は、難治癌である膵癌においてPBK/TOPKの診断・治療標的分子としての可能性を世界に先駆けて検証するものである。PBK/TOPKを標的分子とした新たな治療戦略の構築を可能とする、斬新な研究となるものと考える。