2021 Fiscal Year Final Research Report
Functional analysis of alpha-2-glycoprotein 1, zinc-binding (ZAG) on host im mune response in breast cancer microenvironment.
| Project/Area Number |
20K22856
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0901:Oncology and related fields
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | 乳癌 / 腫瘍免疫 / アンドロゲンレセプター / Alpha-2-glycoprotein 1; / マクロファージ |
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| Outline of Final Research Achievements |
The association between Alpha-2-glycoprotein 1; ZAG expression and the immunological status of breast cancer were analyzed in clinical specimens. We found that ZAG expression was inversely associated with macrophage infiltration into the tumor microenvironment and expression of M1 differentiation marker, CD86. In the M1 / M2 differentiation model system using the macrophage model cell line, THP-1, ZAG did not affect the differentiation of THP-1, but ZAG slightly reduced the expression of a M1 differentiation marker,CD80 in macrophage derived from human peripheral blood.
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| Free Research Field |
腫瘍生物学
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| Academic Significance and Societal Importance of the Research Achievements |
免疫チェックポイント阻害剤が臨床応用された昨今において、は腫瘍微小環境における免疫制御機構をを明らかにすることは新規治療標的の創出や既存の免疫療法の効果的な利用につながる。本研究の結果からAlpha-2-glycoprotein 1; ZAGはマクロファージをはじめとする免疫細胞に働きかけ、乳癌組織における腫瘍免疫を何らかの形で制御している可能性が示唆される。ZAGの免疫系に対する作用の詳細がさらに明らかになれば、腫瘍免疫を応用した治療に対する効果予測マーカーとしての開発やZAGを標的とした治療開発が期待できる。
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