Gastrointestinal microbiome in PDAC

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22858
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Kohi Shiro 産業医科大学, 医学部, 助教 (70886712)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: microbiome / 膵癌

Outline of Final Research Achievements

Recent studies have found that gut microbiome contributes to the pathogenesis of various diseases including PDAC. The outcome of patients with PDAC is associated with their tumor microbiome. However, how the gastrointestinal microbiome involved in pancreatic microbiome remains poorly understood. In this study, we investigated the microbiome alteration in PDAC. We performed 16SrRNA gene sequencing to analyze bacterial profiles. The duodenal microbiome of PDAC patients differed from that of controls. There was evidence of enrichment of periodontal disease-associated bacteria in the duodenal microbiome in patients with PDAC compared to controls. In addition, microbiome analysis using pancreatic tissue suggested that the microbiome may differ between cancerous and normal areas.

Free Research Field

膵癌

Academic Significance and Societal Importance of the Research Achievements

膵癌において歯周病関連の細菌が膵癌進展のリスクファクターであると報告され、注目を集めている。しかしながら、膵癌腫瘍部microbiomeと消化管microbiomeがどのような関連を持っているのかについては不明である。本研究で、歯周病関連の細菌が膵癌の十二指腸microbiomeで多い傾向を認め、口腔内の歯周病関連細菌が膵癌と関係している可能性を認めた。今後、口腔内microbiomeと消化管microbiome、膵臓microbiomeの関連性の検討を行っていくことで、プロバイオティクスや抗生剤投与、さらには口腔内ケアによる膵癌の予防という画期的な治療戦略が期待される。