Relationship between ADLH and atrial fibrillation recurrence following catheter ablation

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K22878
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Kumamoto University
• Principal Investigator: Hoshiyama Tadashi 熊本大学, 病院, 特任講師 (70885590)
• Project Period (FY): 2020-09-11 – 2023-03-31
• Keywords: 心房細動

Outline of Final Research Achievements

The porpose of this study is to investigate the relationship between the ALDH2 gene and atrial fibrillation recurrence following catheter ablation.
The research was started with the policy of conducting a multicenter prospective observational study by three facilities, including this hospital, within the research period. By December 2022, 373 patient registrations have been completed. As soon as the follow-up data is compiled, we plan to announce the results.
In addition, in conducting this study, we investigated the relationship between the ALDH2 gene and the incidence of atrial fibrillation. It turned out to be closely related, leading to the publication of a paper (JACC: Asia 2022:2:62-70).

Free Research Field

不整脈

Academic Significance and Societal Importance of the Research Achievements

研究期間内においてALDH2遺伝子変異型アレルのみでは心房細動との関連は明らかでなかったものの、飲酒習慣を持ったALDH2遺伝子変異型アレル保有者は、より心房細動との関連が高いことが明らかとなった。ただし、サブ解析を行うと若年者（50歳未満）においては解析結果から関連性は明らかとなっておらず、本遺伝子変異保有者は継続的で多年的な飲酒習慣の影響により心房細動を発症してしまっている可能性が高いと思われる。以上より特に、本遺伝子保有者はアルコール摂取を控えることで心房細動発症率を減少させる可能性があると思われる。