Elucidation of regulatory mechanisms of mitochondria regulation by ERAD in failing heart and its therapeutic application.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22902
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Kyushu University
• Principal Investigator: Ikeda Soichiro 九州大学, 医学研究院, 共同研究員 (00885410)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 心不全 / 小胞体 / ミトコンドリア

Outline of Final Research Achievements

In failing heart after myocardial infarction, HERPUD1 protein levels were increased. HERPUD1 was also increased in cardiomyocytes treated with H2O2. Homozygous HERPUD1 knockout mice exacerbated cardiac dysfunction after myocardial infarction. Overexpression of HERPUD1 by adenovirus ameliorated mitochondria dysfunction and cell death in cardiomyocytes treated with H2O2. HERPUD1 may have a protective role in failing heart after myocardial infarction by attenuating mitochondria dysfunction and cardiomyocytes death.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

本研究は心筋細胞における小胞体およびミトコンドリア制御機構を明らかにすることで、心不全の新たな病態機序を明らかにし、加えて新たな新規治療法の開発に発展する可能性がある。